Indications - Lurasidone Hydrochloride is an atypical antipsychotic. This is used for the treatment of: Schizophrenia, Depressive episodes associated with Bipolar I Disorder (bipolar depression), as monotherapy and as adjunctive therapy with lithium or valproate.

Dosage & Administration - Schizophrenia- Starting Dose: 40 mg once daily Recommended Dose: 40 mg to 160 mg once daily Bipolar Depression- Starting Dose: 20 mg once daily Recommended Dose: 20 mg to 120 mg once daily Lurasidone should be taken with food. Administration with food substantially increases the absorption of Lurasidone.

Side Effects - Somnolence, akathisia, extrapyramidal symptoms, and nausea.

Contraindications - Hypersensitivity. Concurrent administration of strong CYP3A4 inhibitors (eg, Ketoconazole). Concurrent administration of strong CYP3A4 inducers (eg, Rifampin). Dementia-related psychosis.

Others - Pregnancy & Lactation Pregnancy Category B. Lurasidone should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Patient should be advised not to breast-feed an infant if they are taking Lurasidone.